Stability and the Biological Activity of Eel Calcitonin in Rats

M. Otani; S. Kitazawa; H. Yamauchi; T. Meguro; Hajime Orimo

doi:10.1055/s-0028-1093447

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Horm Metab Res 1978; 10(3): 252-256
DOI: 10.1055/s-0028-1093447

Originals

Stability and the Biological Activity of Eel Calcitonin in Rats

M. Otani¹ , S. Kitazawa¹ , H. Yamauchi¹ , T. Meguro¹ , Hajime Orimo²

¹Toyo Jozo Co. Ltd. Research Laboratories, Ohito, Shizuoka 410-23
²Section of Endocrinology, Tokyo Metropolitan Geriatric Hospital, Itabashi, Tokyo 1 73, Japan

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Publication History

Publication Date:
23 December 2008 (online)

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Abstract

Hypocalcemic effect in rats of eel calcitonin was more persistent than that of porcine calcitonin and it was as persistent as that of salmon calcitonin I. Eel calcitonin was more stable than porcine or salmon calcitonin I when incubated in vitro with rat or human serum. Incubation in vitro with rat kidney or liver extract for 1 hour at 37 °C caused an almost complete inactivation of porcine calcitonin.

On the other hand, both eel and salmon calcitonin I were inactivated less markedly and in the similar manner. The relationship between the hypocalcemic effect of calcitonins and the inactivation is discussed.

Key words

Calcitonin - Eel - Stability - Hypocalcemic Activity - Calcium

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