Botulinum toxin has been used for temporary muscle paralysis for over 13 years. The off label use of neurotoxins include treatment of dynamic lines on the face and treatment of hyperhidrosis. Several forms of botulinum toxin exist, but only 2 serotypes are available commercially. Botulinum toxin B (BoTX B) is a recently US Food and Drug Administration (FDA) approved neuratoxin used for the treatment of cervical dystonia. Investigations into the use of BoTX B for skin rejuvenation have shown rapid paralysis and reduction of wrinkles. This overview highlights the current reports on the efficacy, duration, and safety of BoTX B when used for cosmetic procedures

The mechanisms of action and recent studies involving clinical cosmetic applications of BoTX B are herein reviewed.