Pictorial ReviewMRI Contrast Agents for Evaluating Focal Hepatic Lesions
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2014, Textbook of Gastrointestinal Radiology: Volumes 1-2, Fourth EditionNanoparticles for improving cancer diagnosis
2013, Materials Science and Engineering R: ReportsCitation Excerpt :They are usually polymers such as polyvinylpyrrolidone (PVP), dendrimers, polyaniline, and dextrans [87–93] which lower the surface energy and increase electrostatic repulsion, resulting in improved colloidal stability. Most IONPs used clinically, including Feridex, Combidex, Resovist, and Ferumoxytol, are made by the co-precipitation method using dextran and its derivatives as the coating materials [94,95]. A sugar coating does not favor direct bio-molecule coupling, and to make the particles conjugation-friendly, a post-synthesis surface engineering step is usually required.
Detection and treatment of intravascular thrombi with magnetofluorescent nanoparticles
2012, Methods in EnzymologyCitation Excerpt :These nanoagents are expected to modulate the pharmacokinetics and biodistribution of the PA, potentially increasing the efficacy of therapy. Dextran-coated monocrystalline iron oxide nanoparticles (MION) have been used clinically for almost two decades and have found utility in the detection of metastases (Harisinghani et al., 2001; Saini et al., 2000), the imaging of angiogenesis (Tang et al., 2005), the examination of primary tumors (Enochs et al., 1999), and the detection of atherosclerotic lesions (Kooi et al., 2003). Their usefulness is a result of their innate localization to inflammatory sites and uptake by phagocytic cells, such as macrophages.
Lysosomal degradation of the carboxydextran shell of coated superparamagnetic iron oxide nanoparticles and the fate of professional phagocytes
2010, BiomaterialsCitation Excerpt :They have no tissue specificity and are excreted through the kidneys. More recently, agents have been introduced that possess longer residence times, mainly because they are recruited intracellularly, and therefore allow extended imaging procedures [6]. Nanosized superparamagnetic iron oxide contrast agents, also called SPIO (“small particle iron oxides” or “superparamagnetic iron oxides”), remain in the circulation for extended periods of time depending on particle size and surface coating.
Molecular imaging: current status and emerging strategies
2010, Clinical RadiologyIron oxide labelling of human mesenchymal stem cells in collagen hydrogels for articular cartilage repair
2008, BiomaterialsCitation Excerpt :SPIO particles are biocompatible because of their biodegradable iron oxide core and their appropriate surface coating, which allows intracellular incorporation [4]. SPIO-based imaging of macrophage activity was the initial and is still the most significant clinical application in this field, in particular for tumour staging of the liver and lymph nodes [6,7]. As a valuable tool in preclinical research, various non-phagocytic cells, including MSCs, were previously labelled in culture with SPIO particles [8–13].
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Author for correspondence and guarantor of study: Dr Mukesh G. Harisinghani, Division of Abdominal and Interventional Radiology, White 270, Massachusetts General Hospital, Boston, MA 02114, U.S.A. Fax: +1 617 726 4891; E-mail: [email protected]