Issue 28, 2021

Tandem elimination-oxidation of tertiary benzylic alcohols with an oxoammonium salt

Abstract

Tertiary benzylic alcohols react with oxoammonium salts, undergoing a tandem elimination/allylic oxidation to provide an allylic ether product in a single step. This mode of reactivity provides a rapid entry into allylic ethers from certain benzylic tertiary alcohols. The allylic ether may be cleaved under reductive conditions to reveal the allylic alcohol.

Graphical abstract: Tandem elimination-oxidation of tertiary benzylic alcohols with an oxoammonium salt

Supplementary files

Article information

Article type
Communication
Submitted
18 May 2021
Accepted
30 Jun 2021
First published
30 Jun 2021

Org. Biomol. Chem., 2021,19, 6233-6236

Tandem elimination-oxidation of tertiary benzylic alcohols with an oxoammonium salt

R. I. L. Meador, R. E. Anderson and J. D. Chisholm, Org. Biomol. Chem., 2021, 19, 6233 DOI: 10.1039/D1OB00965F

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