Development of potent inhibitors for strigolactone receptor DWARF 14

Masahiko Yoshimura; Sojung F. Kim; Ryosuke Takise; Shuhei Kusano; Sakuya Nakamura; Masanori Izumi; Akiko Yagi; Kenichiro Itami; Shinya Hagihara

doi:10.1039/D0CC01989E

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Development of potent inhibitors for strigolactone receptor DWARF 14†

Masahiko Yoshimura,‡^a Sojung F. Kim,‡^bc Ryosuke Takise,‡^a Shuhei Kusano,

^d Sakuya Nakamura,

^d Masanori Izumi,

^d Akiko Yagi,^a Kenichiro Itami

^ac and Shinya Hagihara

*^cd

Author affiliations

* Corresponding authors

^a Graduate School of Science Nagoya University, Chikusa, Nagoya, Japan

^b Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA

^c Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Chikusa, Nagoya, Japan

^d Center for Sustainable Resource Science, RIKEN, 2-1 Hirosawa, Wako City, Saitama, Japan

Abstract

Strigolactones (SLs) are plant hormones that suppress shoot branching through perception by their receptor protein DWARF 14 (D14). The artificial regulation of SL signaling has been considered a potent agricultural technique because plant architecture is strongly related to crop yield. In this communication, we describe the development of a small-molecule D14 inhibitor that functions at sub-micromolar levels. This potent inhibitor may be a lead compound for a first-in-class plant growth regulator.

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DOI: https://doi.org/10.1039/D0CC01989E
Article type: Communication
Submitted: 17 Mar 2020
Accepted: 26 Oct 2020
First published: 16 Nov 2020

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Chem. Commun., 2020,56, 14917-14919

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Development of potent inhibitors for strigolactone receptor DWARF 14

M. Yoshimura, S. F. Kim, R. Takise, S. Kusano, S. Nakamura, M. Izumi, A. Yagi, K. Itami and S. Hagihara, Chem. Commun., 2020, 56, 14917 DOI: 10.1039/D0CC01989E

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Chemical Communications

Development of potent inhibitors for strigolactone receptor DWARF 14†

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Development of potent inhibitors for strigolactone receptor DWARF 14

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