Issue 49, 2020
From the journal:

Chemical Communications

Three-dimensional DNA nanostructures for dual-color microRNA imaging in living cells via hybridization chain reaction†

Meng-Mei Lv,a   Zhan Wu, ORCID logo *b   Ru-Qin Yu ORCID logo a  and  Jian-Hui Jiang ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China
E-mail: jianhuijiang@hnu.edu.cn
Fax: +86-731-88822577
Tel: +86-731-88822872

b Key Laboratory of Phytochemical R&D of Hunan Province, and Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education of China), Hunan Normal University, Changsha 410081, China
E-mail: zhanwu@hunnu.edu.cn

Abstract

A well-defined 3D DNA nanostructure with precise composition was developed by stoichimetric combination of a DNA tetrahedron and Y-shaped DNA, which allowed multiplexed, signal-amplified fluorescence imaging of miRNAs in living cells via hybridization chain reaction.

Graphical abstract: Three-dimensional DNA nanostructures for dual-color microRNA imaging in living cells via hybridization chain reaction

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Article information

DOI
https://doi.org/10.1039/D0CC01626H
Article type
Communication
Submitted
02 Mar 2020
Accepted
24 Apr 2020
First published
29 Apr 2020

Chem. Commun., 2020,56, 6668-6671

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Three-dimensional DNA nanostructures for dual-color microRNA imaging in living cells via hybridization chain reaction

M. Lv, Z. Wu, R. Yu and J. Jiang, Chem. Commun., 2020, 56, 6668 DOI: 10.1039/D0CC01626H

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