Issue 34, 2019
From the journal:

Journal of Materials Chemistry B

Bacteria-assisted biogreen synthesis of radical scavenging exopolysaccharide–iron complexes: an oral nano-sized nutritional supplement with high in vivo compatibility†

Seyyed Vahid Niknezhad,ab   Ghasem Najafpour Darzi,a   Sedigheh Kianpour,b   Sina Jafarzadeh,c   Hamidreza Mohammadi,b   Younes Ghasemi,bd   Reza Heidari*b  and  Mohammad-Ali Shahbazi ORCID logo *ef  

* Corresponding authors

a Department of Chemical Engineering, Faculty of Engineering, Noshirvani University of Technology, Babol, Iran

b Pharmaceutical Sciences Research Centre, Shiraz University of Medical Sciences, P.O. Box 71345-1583, Shiraz, Iran

c Department of Chemical and Petroleum Engineering, Sharif University of Technology, P.O. Box 11365-11155, Tehran, Iran

d Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, P.O. Box 71345-1583, Shiraz, Iran

e Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki FI-00014, Finland
E-mail: m.a.shahbazi@helsinki.fi

f Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran

Abstract

Microbial exopolysaccharides (EPSs) have recently served as an efficient substrate for the production of biocompatible metal nanoparticles (NPs) given their favorable stabilizing and reducing properties due to the presence of polyanionic functional groups in their structure. In the present work, Pantoea sp. BCCS 001 GH was used to produce EPS-stabilized biogenic Fe NPs as a complex through a novel biosynthesis reaction. Physicochemical characterization of the EPS–Fe complex was performed, indicating high thermal stability, desirable magnetic properties due to the uniform distribution of the Fe NPs with the average size of ∼10 nm and spherical shape within the EPS matrix. In addition, the in vivo toxicity of the EPS-stabilized Fe NPs was evaluated to investigate their potential for the treatment of iron deficiency anemia. Biological blood parameters and organ histology studies confirmed very high safety of the biosynthesized composite, making EPS–Fe a suitable candidate with an economical and environment friendly synthesis method for a wide spectrum of potential fields in medicine.

Graphical abstract: Bacteria-assisted biogreen synthesis of radical scavenging exopolysaccharide–iron complexes: an oral nano-sized nutritional supplement with high in vivo compatibility

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Article information

DOI
https://doi.org/10.1039/C9TB01077G
Article type
Paper
Submitted
29 May 2019
Accepted
22 Jul 2019
First published
22 Jul 2019

J. Mater. Chem. B, 2019,7, 5211-5221

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Bacteria-assisted biogreen synthesis of radical scavenging exopolysaccharide–iron complexes: an oral nano-sized nutritional supplement with high in vivo compatibility

S. V. Niknezhad, G. Najafpour Darzi, S. Kianpour, S. Jafarzadeh, H. Mohammadi, Y. Ghasemi, R. Heidari and M. Shahbazi, J. Mater. Chem. B, 2019, 7, 5211 DOI: 10.1039/C9TB01077G

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