Issue 20, 2019

Photocatalytic aerobic α-thiolation/annulation of carbonyls with mercaptobenzimidazoles

Abstract

A concise aerobic photocatalysis using a blue LED combined with a Lewis acid has been developed to enable α-thiolation/annulation of carbonyls. Inexpensive, nontoxic Rose Bengal was demonstrated as the best catalyst. Hence, this transition-metal-free protocol allows mild Csp3–S couplings with both ketones and aliphatic aldehydes with a range of compatible useful functionalities.

Graphical abstract: Photocatalytic aerobic α-thiolation/annulation of carbonyls with mercaptobenzimidazoles

Supplementary files

Article information

Article type
Communication
Submitted
17 Mar 2019
Accepted
29 Apr 2019
First published
29 Apr 2019

Org. Biomol. Chem., 2019,17, 4979-4983

Photocatalytic aerobic α-thiolation/annulation of carbonyls with mercaptobenzimidazoles

X. Ji, M. Tan, M. Fu, G. Deng and H. Huang, Org. Biomol. Chem., 2019, 17, 4979 DOI: 10.1039/C9OB00625G

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