Issue 12, 2019
From the journal:

Chemical Communications

Engineering of a bioluminescent probe for imaging nitroxyl in live cells and mice†

Jun-Bin Li,a   Qianqian Wang,a   Hong-Wen Liu, ORCID logo a   Xia Yin,*a   Xiao-Xiao Hu,a   Lin Yuan ORCID logo a  and  Xiao-Bing Zhang ORCID logo *a  

* Corresponding authors

a Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, Hunan University, Changsha 410082, China
E-mail: xbzhang@hnu.edu.cn

Abstract

A bioluminescent probe, BP-HNO, which exhibits a turn-on response to nitroxyl with high sensitivity and selectivity, is reported for the first time in this work. BP-HNO is free from the interference of biological autofluorescence to afford a high signal-to-noise ratio for bioimaging, and was successfully applied to imaging nitroxyl in live cells and mice.

Graphical abstract: Engineering of a bioluminescent probe for imaging nitroxyl in live cells and mice

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Article information

DOI
https://doi.org/10.1039/C9CC00211A
Article type
Communication
Submitted
09 Jan 2019
Accepted
14 Jan 2019
First published
15 Jan 2019

Chem. Commun., 2019,55, 1758-1761

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Engineering of a bioluminescent probe for imaging nitroxyl in live cells and mice

J. Li, Q. Wang, H. Liu, X. Yin, X. Hu, L. Yuan and X. Zhang, Chem. Commun., 2019, 55, 1758 DOI: 10.1039/C9CC00211A

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