Issue 4, 2019

Base-promoted direct synthesis of functionalized N-arylindoles via the cascade reactions of allenic ketones with indoles

Abstract

A convenient Cs2CO3-promoted cascade benzannulation reaction of allenic ketones with indoles was achieved for the synthesis of functionalized N-arylindole derivatives under transition-metal-free conditions. A series of readily available starting materials can undergo the process successfully. It represents a practical method for the construction of N-arylindole scaffolds with high atom economy.

Graphical abstract: Base-promoted direct synthesis of functionalized N-arylindoles via the cascade reactions of allenic ketones with indoles

Supplementary files

Article information

Article type
Communication
Submitted
23 Nov 2018
Accepted
27 Dec 2018
First published
28 Dec 2018

Org. Biomol. Chem., 2019,17, 789-793

Base-promoted direct synthesis of functionalized N-arylindoles via the cascade reactions of allenic ketones with indoles

S. Li, X. Wu and S. Chen, Org. Biomol. Chem., 2019, 17, 789 DOI: 10.1039/C8OB02921K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements