Inhibitor structure-guided design and synthesis of near-infrared fluorescent probes for monoamine oxidase A (MAO-A) and its application in living cells and in vivo

Zhengmin Yang; Wenxiu Li; Hua Chen; Qingyuan Mo; Jun Li; Shulin Zhao; Cheng Hou; Jiangke Qin; Guifa Su

doi:10.1039/C8CC10084E

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Inhibitor structure-guided design and synthesis of near-infrared fluorescent probes for monoamine oxidase A (MAO-A) and its application in living cells and in vivo†

Zhengmin Yang,^ab Wenxiu Li,^a Hua Chen,

^a Qingyuan Mo,^a Jun Li,*^a Shulin Zhao,

^a Cheng Hou,^a Jiangke Qin

*^a and Guifa Su^a

Author affiliations

* Corresponding authors

^a State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, P. R. China
E-mail: lijun9593@163.com, jiangkeq@sina.com

^b Qiannan Medical College for Nationalities, Duyun, P. R. China

Abstract

A series of near-infrared fluorescent probes based on inhibitor (clorgyline) structure-guided design were synthesized for the specific detection of MAO-A in cells and in vivo. Moreover, we have successfully used the high specificity of one of the probes to visualize MAO-A activity in zebrafish and tumor tissue for the first time.

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Article information

DOI: https://doi.org/10.1039/C8CC10084E
Article type: Communication
Submitted: 20 Dec 2018
Accepted: 30 Jan 2019
First published: 31 Jan 2019

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Chem. Commun., 2019,55, 2477-2480

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Inhibitor structure-guided design and synthesis of near-infrared fluorescent probes for monoamine oxidase A (MAO-A) and its application in living cells and in vivo

Z. Yang, W. Li, H. Chen, Q. Mo, J. Li, S. Zhao, C. Hou, J. Qin and G. Su, Chem. Commun., 2019, 55, 2477 DOI: 10.1039/C8CC10084E

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Chemical Communications

Inhibitor structure-guided design and synthesis of near-infrared fluorescent probes for monoamine oxidase A (MAO-A) and its application in living cells and in vivo†

Abstract

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Inhibitor structure-guided design and synthesis of near-infrared fluorescent probes for monoamine oxidase A (MAO-A) and its application in living cells and in vivo

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