Co-assembling FRET nanomedicine with self-indicating drug release

Yang Li; Jiao Zhu; Tianyi Kang; Yuwen Chen; Yu Liu; Yulan Huang; Yi Luo; Meijuan Huang; Maling Gou

doi:10.1039/C8CC06792A

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Co-assembling FRET nanomedicine with self-indicating drug release†

Yang Li,‡^a Jiao Zhu,‡^b Tianyi Kang,^a Yuwen Chen,^a Yu Liu,^a Yulan Huang,^a Yi Luo,^ac Meijuan Huang^b and Maling Gou

*^a

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* Corresponding authors

^a Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China
E-mail: goumaling@scu.edu.cn

^b Department of Thoracic Oncology, Cancer Center, West China Hospital, Medical School, Sichuan University, Chengdu, China

^c Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, China

Abstract

Two lipophilic fluorescent prodrugs co-assembled into nanoaggregates with the ability to release FRET-indicated drugs, which was used to investigate the role of reduction-responsive linkers on drug release kinetics in the cytoplasm and physiologically relevant media in a visualized, noninvasive manner.

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Article information

DOI: https://doi.org/10.1039/C8CC06792A
Article type: Communication
Submitted: 21 Aug 2018
Accepted: 18 Sep 2018
First published: 20 Sep 2018

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Chem. Commun., 2018,54, 11618-11621

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Co-assembling FRET nanomedicine with self-indicating drug release

Y. Li, J. Zhu, T. Kang, Y. Chen, Y. Liu, Y. Huang, Y. Luo, M. Huang and M. Gou, Chem. Commun., 2018, 54, 11618 DOI: 10.1039/C8CC06792A

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Chemical Communications

Co-assembling FRET nanomedicine with self-indicating drug release†

Abstract

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Co-assembling FRET nanomedicine with self-indicating drug release

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