Issue 40, 2017

Ultrasmall and photostable nanotheranostic agents based on carbon quantum dots passivated with polyamine-containing organosilane molecules

Abstract

In this work, we demonstrate that ultrasmall, photostable and multifunctional carbon quantum dots (or carbon dots, CDs) passivated with polyamine-containing organosilane molecules can realize simultaneous cell imaging and anticancer drug delivery. The presence of abundant surface amine groups makes these CDs be able to covalently link with the anticancer drug, doxorubicin (DOX), with an extremely high drug loading capacity (62.8%), while the surface hydroxyl groups ensure the good water-dispersibility of the CDs–DOX. Besides the use as a drug carrier, the fluorescent CDs also enable the dynamic tracing of the drug release process. When the CDs–DOX complexes were internalized by the human breast cancer cells (MCF-7), DOX could gradually detach from the surface of CDs and enter into the cell nucleus, while the CDs themselves still resided in the cytoplasm. In addition, the in vivo experiments showed that the CDs–DOX complexes exhibited a better tumor inhibition performance than free DOX molecules, which may be ascribed to the prolonged drug accumulation in tumor tissues. Furthermore, the as-synthesized CDs also exhibited negligible cytotoxicity/systemic side effects, and could successfully illuminate mammalian, bacterial and fungal cells, making them good candidates as not only drug delivery vehicles but also universal cell imaging reagents. The present work may have implications for the fabrication of functional carbon-based nanomaterials and foster the development of carbon dots as novel nanotheranostics for various biomedical applications.

Graphical abstract: Ultrasmall and photostable nanotheranostic agents based on carbon quantum dots passivated with polyamine-containing organosilane molecules

Supplementary files

Article information

Article type
Paper
Submitted
30 Jul 2017
Accepted
08 Sep 2017
First published
11 Sep 2017

Nanoscale, 2017,9, 15441-15452

Ultrasmall and photostable nanotheranostic agents based on carbon quantum dots passivated with polyamine-containing organosilane molecules

J. Yang, G. Gao, X. Zhang, Y. Ma, H. Jia, Y. Jiang, Z. Wang and F. Wu, Nanoscale, 2017, 9, 15441 DOI: 10.1039/C7NR05613C

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