Issue 10, 2017

A bioorthogonal ‘turn-on’ fluorescent probe for tracking mitochondrial nitroxyl formation

Abstract

A bioreductant-resistant ‘turn-on’ chemodosimetric fluorescent probe Mito-1 has been developed for the detection of mitochondrial HNO in live cells. Mito-1 enables the detection of HNO as low as ∼18 nM. It has the capability to detect both exogenous and endogenous mitochondrial HNO formations in cellular milieus by providing fluorescence images. Its two-photon imaging ability fosters its use as a noninvasive imaging tool for the detection of mitochondrial nitroxyl.

Graphical abstract: A bioorthogonal ‘turn-on’ fluorescent probe for tracking mitochondrial nitroxyl formation

Supplementary files

Article information

Article type
Communication
Submitted
14 Nov 2016
Accepted
10 Jan 2017
First published
10 Jan 2017

Chem. Commun., 2017,53, 1723-1726

A bioorthogonal ‘turn-on’ fluorescent probe for tracking mitochondrial nitroxyl formation

K. Sunwoo, K. N. Bobba, J. Lim, T. Park, A. Podder, J. S. Heo, S. G. Lee, S. Bhuniya and J. S. Kim, Chem. Commun., 2017, 53, 1723 DOI: 10.1039/C6CC09082F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements