Issue 48, 2016
From the journal:

Chemical Communications

A pH-responsive DNA nanomachine-controlled catalytic assembly of gold nanoparticles†

Dongbao Yao,a   Hui Li,a   Yijun Guo,a   Xiang Zhou,a   Shiyan Xiao*a  and  Haojun Liang*ab  

* Corresponding authors

a CAS Key Laboratory of Soft Matter Chemistry, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China
E-mail: xiaosy@ustc.edu.cn, hjliang@ustc.edu.cn

b Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China

Abstract

The toehold-mediated DNA-strand-displacement reaction has unique programmable properties for driving the catalytic assembly of gold nanoparticles (AuNPs). Herein, we introduced a pH-responsive triplex structure into the DNA-strand-displacement-based catalytic assembly system of DNA–AuNPs to add an additional controlling factor, namely the pH. In this catalytic system, the aggregation rate of AuNPs could be regulated by both internal factors (concentrations of substrate, target, etc.) and an external control (pH gradient). This strategy can be used to construct pH-induced DNA logic gates and sophisticated DNA networks as well as to image instantaneous pH changes in living cells.

Graphical abstract: A pH-responsive DNA nanomachine-controlled catalytic assembly of gold nanoparticles

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Article information

DOI
https://doi.org/10.1039/C6CC03089K
Article type
Communication
Submitted
13 Apr 2016
Accepted
10 May 2016
First published
10 May 2016

Chem. Commun., 2016,52, 7556-7559

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A pH-responsive DNA nanomachine-controlled catalytic assembly of gold nanoparticles

D. Yao, H. Li, Y. Guo, X. Zhou, S. Xiao and H. Liang, Chem. Commun., 2016, 52, 7556 DOI: 10.1039/C6CC03089K

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