Issue 58, 2015
From the journal:

Chemical Communications

Antimicrobial peptide shows enhanced activity and reduced toxicity upon grafting to chitosan polymers†

Priyanka Sahariah,a   Kasper K. Sørensen,b   Martha Á. Hjálmarsdóttir,c   Ólafur E. Sigurjónsson,de   Knud J. Jensen,b   Már Másson*a  and  Mikkel B. Thygesen*b  

* Corresponding authors

a Faculty of Pharmaceutical Sciences, School of Health Sciences, University of Iceland, Hofsvallagata 53, IS-107 Reykjavík, Iceland

b Department of Chemistry, Faculty of Science, Centre for Carbohydrate Recognition and Signalling, University of Copenhagen, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Copenhagen, Denmark
E-mail: mbth@chem.ku.dk

c Department of Biomedical Science, Faculty of Medicine, University of Iceland, Stapi, Hringbraut 31, 101 Reykjavík, Iceland

d The REModeL Lab, The Blood Bank, Landspitali University Hospital, Snorrabraut 60, 105 Reykjavik, Iceland

e Institute of Biomedical and Neural Engineering, Reykjavik University, Menntavegur 1, Reykjavik, Iceland

Abstract

Here we report that grafting of a short antimicrobial peptide, anoplin, to chitosan polymers is a strategy for abolishing the hemolytic propensity, and at the same time increasing the activity of the parent peptide. Anoplin–chitosan conjugates were synthesized by CuAAC reaction of multiple peptides through 2-azidoacetyl groups on chitosan.

Graphical abstract: Antimicrobial peptide shows enhanced activity and reduced toxicity upon grafting to chitosan polymers

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Article information

DOI
https://doi.org/10.1039/C5CC04010H
Article type
Communication
Submitted
18 May 2015
Accepted
15 Jun 2015
First published
15 Jun 2015

Chem. Commun., 2015,51, 11611-11614

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Antimicrobial peptide shows enhanced activity and reduced toxicity upon grafting to chitosan polymers

P. Sahariah, K. K. Sørensen, M. Á. Hjálmarsdóttir, Ó. E. Sigurjónsson, K. J. Jensen, M. Másson and M. B. Thygesen, Chem. Commun., 2015, 51, 11611 DOI: 10.1039/C5CC04010H

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