Issue 6, 2015
From the journal:

Biomaterials Science

Protein nanoparticles for therapeutic protein delivery

L. P. Herrera Estradaa  and  J. A. Champion*a  

* Corresponding authors

a School of Chemical & Biomolecular Engineering. Georgia Institute of Technology, 311 Ferst Drive NW, Atlanta, GA 30332-0100, USA
E-mail: julie.champion@chbe.gatech.edu

Abstract

Therapeutic proteins can face substantial challenges to their activity, requiring protein modification or use of a delivery vehicle. Nanoparticles can significantly enhance delivery of encapsulated cargo, but traditional small molecule carriers have some limitations in their use for protein delivery. Nanoparticles made from protein have been proposed as alternative carriers and have benefits specific to therapeutic protein delivery. This review describes protein nanoparticles made by self-assembly, including protein cages, protein polymers, and charged or amphipathic peptides, and by desolvation. It presents particle fabrication and delivery characterization for a variety of therapeutic and model proteins, as well as comparison of the features of different protein nanoparticles.

Graphical abstract: Protein nanoparticles for therapeutic protein delivery

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Article information

DOI
https://doi.org/10.1039/C5BM00052A
Article type
Review Article
Submitted
17 Feb 2015
Accepted
02 May 2015
First published
13 May 2015

Biomater. Sci., 2015,3, 787-799

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Protein nanoparticles for therapeutic protein delivery

L. P. Herrera Estrada and J. A. Champion, Biomater. Sci., 2015, 3, 787 DOI: 10.1039/C5BM00052A

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