Issue 35, 2014
From the journal:

Organic & Biomolecular Chemistry

A general catalyst for Suzuki–Miyaura and Sonogashira reactions of aryl and heteroaryl chlorides in water†

Hui Peng,a   Ya-Qin Chen,b   Shu-Lan Mao,c   Yun-Xiao Pi,a   You Chen,a   Ze-Yu Lian,a   Tong Meng,a   Sheng-Hua Liu*a  and  Guang-Ao Yu*a  

* Corresponding authors

a Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, People's Republic of China
E-mail: yuguang@mail.ccnu.edu.cn, chshliu@mail.ccnu.edu.cn

b Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China

c State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, People's Republic of China

Abstract

We report the synthesis of 2-(3-sulfonatomesityl)-5-sulfonatoindenyl)dicyclohexylphosphine hydrate sodium salt and its use in palladium-catalyzed Suzuki–Miyaura and Sonogashira coupling reactions in water (and biphasic water–organic solvent mixtures) to prepare a variety of functionalized biaryls and aryl alkynes in excellent yield.

Graphical abstract: A general catalyst for Suzuki–Miyaura and Sonogashira reactions of aryl and heteroaryl chlorides in water

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Article information

DOI
https://doi.org/10.1039/C4OB00846D
Article type
Paper
Submitted
24 Apr 2014
Accepted
16 Jul 2014
First published
16 Jul 2014

Org. Biomol. Chem., 2014,12, 6944-6952

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A general catalyst for Suzuki–Miyaura and Sonogashira reactions of aryl and heteroaryl chlorides in water

H. Peng, Y. Chen, S. Mao, Y. Pi, Y. Chen, Z. Lian, T. Meng, S. Liu and G. Yu, Org. Biomol. Chem., 2014, 12, 6944 DOI: 10.1039/C4OB00846D

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