Issue 73, 2014
From the journal:

Chemical Communications

Copper-catalyzed intermolecular azidocyanation of aryl alkenes†‡

Li Xu,a   Xue-Qing Mou,a   Zhi-Min Chenb  and  Shao-Hua Wang*ab  

* Corresponding authors

a School of Pharmacy, Lanzhou University, Lanzhou 730000, P. R. China
E-mail: wangshh@lzu.edu.cn

b State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China

Abstract

A copper-catalyzed Markovnikov-type intermolecular azidocyanation of aryl alkenes has been developed to give a series of α-azido-propanenitriles in moderate to good yields. This method may provide a potential strategy for the synthesis of corresponding 3-amino-2-arylpropanoic acid.

Graphical abstract: Copper-catalyzed intermolecular azidocyanation of aryl alkenes

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Article information

DOI
https://doi.org/10.1039/C4CC04640D
Article type
Communication
Submitted
18 Jun 2014
Accepted
18 Jul 2014
First published
18 Jul 2014

Chem. Commun., 2014,50, 10676-10679

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Copper-catalyzed intermolecular azidocyanation of aryl alkenes

L. Xu, X. Mou, Z. Chen and S. Wang, Chem. Commun., 2014, 50, 10676 DOI: 10.1039/C4CC04640D

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