Issue 88, 2014
From the journal:

Chemical Communications

Efficient approach to prepare multiple chemotherapeutic agent conjugated nanocarrier†

Vijayakameswara Rao N,a   Himadri Dinda,a   Mutyala Naidu Ganivada,a   Jayasri Das Sarma*b  and  Raja Shunmugam*a  

* Corresponding authors

a Polymer Research Centre, Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, India
E-mail: sraja@iiserkol.ac.in

b Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, India

Abstract

A pH-responsive, multiple chemotherapeutic agent derived nanocarrier has been synthesized by conjugating doxorubicin, indomethacin, and folate to the backbone of norbornene polymer. Drug molecules are connected to the norbornene backbone by an ester linker to demonstrate the pH-responsive capabilities. The complete chemical and biological properties of the new norbornene-based polymeric nanocarrier, intended for combination cancer chemotherapy, are discussed.

Graphical abstract: Efficient approach to prepare multiple chemotherapeutic agent conjugated nanocarrier

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Article information

DOI
https://doi.org/10.1039/C4CC04445B
Article type
Communication
Submitted
11 Jun 2014
Accepted
03 Sep 2014
First published
03 Sep 2014

Chem. Commun., 2014,50, 13540-13543

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Efficient approach to prepare multiple chemotherapeutic agent conjugated nanocarrier

V. R. N, H. Dinda, M. N. Ganivada, J. Das Sarma and R. Shunmugam, Chem. Commun., 2014, 50, 13540 DOI: 10.1039/C4CC04445B

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