Issue 47, 2014
From the journal:

Chemical Communications

Reporter-triggered isothermal exponential amplification strategy in ultrasensitive homogeneous label-free electrochemical nucleic acid biosensing†

Ji Nie,a   De-Wen Zhang,a   Fang-Ting Zhang,a   Fang Yuan,a   Ying-Lin Zhou*a  and  Xin-Xiang Zhang*a  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences (BNLMS), MOE Key Laboratory of Bioorganic Chemistry and Molecular Engineering, College of Chemistry, Peking University, Beijing 100871, China
E-mail: zhouyl@pku.edu.cn, zxx@pku.edu.cn
Fax: +86-10-62754112
Tel: +86-10-62754112

Abstract

A simple and novel reporter-triggered isothermal exponential amplification reaction (R-EXPAR) integrated with a miniaturized electrochemical device was developed, which achieved excellent improvement (five orders of magnitude) of sensitivity toward reporter, G-quadruplex. This R-EXPAR strategy has been successfully implemented to construct a homogeneous label-free electrochemical sensor for ultrasensitive DNA detection.

Graphical abstract: Reporter-triggered isothermal exponential amplification strategy in ultrasensitive homogeneous label-free electrochemical nucleic acid biosensing

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Article information

DOI
https://doi.org/10.1039/C4CC00475B
Article type
Communication
Submitted
20 Jan 2014
Accepted
12 Mar 2014
First published
13 Mar 2014

Chem. Commun., 2014,50, 6211-6213

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Reporter-triggered isothermal exponential amplification strategy in ultrasensitive homogeneous label-free electrochemical nucleic acid biosensing

J. Nie, D. Zhang, F. Zhang, F. Yuan, Y. Zhou and X. Zhang, Chem. Commun., 2014, 50, 6211 DOI: 10.1039/C4CC00475B

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