Issue 29, 2013
From the journal:

Organic & Biomolecular Chemistry

Synthesis and biological evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives

P. Horrocks,*a   M. R. Pickard,a   H. H. Parekh,b   S. P. Patelbc  and  Ravindra B. Pathak*ab  

* Corresponding authors

a Institute for Sciences and Technology in Medicine, Keele University, Staffordshire, Keele, UK
E-mail: r.pathak@keele.ac.uk

b Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India

c Aptuit LLC, 10245, Hickman Mills Drive, Kansas City, MO 64134-9724, USA

Abstract

3-(4-Chlorophenyl)-4-substituted pyrazole derivatives were synthesised and tested for their in vitro antifungal activity. Some compounds showed very good antifungal activity against four pathogenic strains of fungi. The same compounds exhibited an interesting activity against the tested strain of Mycobacterium tuberculosis H37Rv. The results suggest that 1,3,4-oxadiazoles and 5-pyrazolinones bearing a core pyrazole scaffold may be promising antifungal and antitubercular agents.

Graphical abstract: Synthesis and biological evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives

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Article information

DOI
https://doi.org/10.1039/C3OB27290G
Article type
Paper
Submitted
26 Nov 2012
Accepted
31 May 2013
First published
12 Jun 2013

Org. Biomol. Chem., 2013,11, 4891-4898

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Synthesis and biological evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives

P. Horrocks, M. R. Pickard, H. H. Parekh, S. P. Patel and R. B. Pathak, Org. Biomol. Chem., 2013, 11, 4891 DOI: 10.1039/C3OB27290G

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