Issue 28, 2013
From the journal:

Dalton Transactions

Magnetism and spin dynamics of novel encapsulated iron oxide superparamagnetic nanoparticles†

Paolo Arosio,a   Giovanni Baldi,b   Federica Chiellini,c   Maurizio Corti,d   Alberto Dessy,c   Pietro Galinetto,d   Matteo Gazzarri,c   Marco Simone Grandi,d   Claudia Innocenti,e   Alessandro Lascialfari,*ad   Giada Lorenzi,b   Francesco Orsini,a   Anna Maria Piras,c   Costanza Ravaglib  and  Claudio Sangregorioef  

* Corresponding authors

a Dipartimento di Fisica, Università degli Studi di Milano, I-20133 Milano, and Consorzio INSTM, Milano Unit, Italy
E-mail: alessandro.lascialfari@unimi.it

b CERICOL, Colorobbia, via Pietramarina 123, 50053 Sovigliana – Vinci, Firenze, Italy

c BIOlab, Laboratorio di Materiali Polimerici Bioattivi per Applicazioni Biomediche ed Ambientali, Dipartimento di Chimica e Chimica Industriale, Università di Pisa, UdR INSTM, Italy

d Università degli Studi di Pavia, Dipartimento di Fisica, I-27100, Pavia, and Consorzio INSTM, Pavia Unit, Italy

e Dipartimento di Chimica “Ugo Shiff”, Università degli Studi di Firenze, via della Lastruccia 3-13, 50019 Sesto Fiorentino (Firenze), and INSTM, Research Unit of Florence – Italy

f CNR-ISTM, via Camillo Golgi, 20123 Milano, Italy

Abstract

Encapsulated Fe3O4 nanoparticles of average diameters d = 12 nm are obtained by coprecipitation, in the presence of 2-methoxyethanol hemiester of poly(maleic anhydride-alt-butyl vinyl ether) 5% grafted with poly(ethylene glycol) (VP-MAG nanoparticles). A complete characterization of nude and encapsulated nanoparticles through structural techniques (namely XRD, TEM, SEM), Raman spectroscopy and magnetic measurements has been performed. These nanoparticles compared with commercial compounds (ENDOREM®) present superparamagnetic behavior and nuclear relaxivities that make them promising as magnetic resonance imaging (MRI) contrast agents (CAs). We found that our nanostructures exhibit r2 relaxivity higher than those of commercial CAs over the whole frequency range. The MRI efficiency of our samples was related to their microstructural and magnetic properties.

Graphical abstract: Magnetism and spin dynamics of novel encapsulated iron oxide superparamagnetic nanoparticles

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Article information

DOI
https://doi.org/10.1039/C3DT32805H
Article type
Paper
Submitted
23 Nov 2012
Accepted
08 May 2013
First published
10 May 2013

Dalton Trans., 2013,42, 10282-10291

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Magnetism and spin dynamics of novel encapsulated iron oxide superparamagnetic nanoparticles

P. Arosio, G. Baldi, F. Chiellini, M. Corti, A. Dessy, P. Galinetto, M. Gazzarri, M. S. Grandi, C. Innocenti, A. Lascialfari, G. Lorenzi, F. Orsini, A. M. Piras, C. Ravagli and C. Sangregorio, Dalton Trans., 2013, 42, 10282 DOI: 10.1039/C3DT32805H

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