Issue 10, 2013

Design of chemical glycosyl donors: does changing ring conformation influence selectivity/reactivity?

Abstract

This tutorial review focuses on the design of glycosyl donors, especially on attempts to control selectivity/reactivity by employing bulky substituents, cyclic protecting groups, or bridged structures. These structural modifications are performed to change the conformational distributions of pyranoside/furanoside rings. We also briefly discuss this issue with regard to studies on furanosides and enzymatic glycosylation reactions. Readers will find that some of the designed glycosyl donors have been used to achieve total syntheses of natural products.

Graphical abstract: Design of chemical glycosyl donors: does changing ring conformation influence selectivity/reactivity?

Article information

Article type
Tutorial Review
Submitted
08 Nov 2012
First published
30 Jan 2013

Chem. Soc. Rev., 2013,42, 4297-4309

Design of chemical glycosyl donors: does changing ring conformation influence selectivity/reactivity?

H. Satoh and S. Manabe, Chem. Soc. Rev., 2013, 42, 4297 DOI: 10.1039/C3CS35457A

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