Size tunable fluorescent nano-graphite oxides: preparation and cell imaging applications

Xiaoyong Zhang; Shiqi Wang; Meiying Liu; Bin Yang; Lin Feng; Yan Ji; Lei Tao; Yen Wei

doi:10.1039/C3CP52883A

Size tunable fluorescent nano-graphite oxides: preparation and cell imaging applications†

Xiaoyong Zhang,^a Shiqi Wang,^a Meiying Liu,^b Bin Yang,^a Lin Feng,^a Yan Ji,^a Lei Tao*^a and Yen Wei*^a

* Corresponding authors

^a Department of Chemistry, the Tsinghua Center for Frontier Polymer Research, Tsinghua University, Beijing, P. R. China
E-mail: leitao@mail.tsinghua.edu.cn, weiyen@tsinghua.edu.cn

^b Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Organic Solids, Laboratory of New Materials, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China

Abstract

Fluorescent nano-graphite oxides (NGO) with different size distribution were prepared via a one-pot hydrothermal route using ultrasmall graphite powder as starting material and subsequently separated using dialysis tubes with different molecular weight cutoff. The biomedical applications of these NGO for cell imaging were further investigated. Fourier transform infrared spectra demonstrated that many functional groups including the hydroxyl group, carboxyl group and epoxy group were present on NGO, which endowed them with good water solubility. These NGO showed size-dependent photoluminescence and excellent biocompatibility with A549 cells. As evidenced by laser scanning confocal microscopy images, NGO could be internalized by A549 cells and located in the cytoplasm. Given their good water solubility, size tunable photoluminescence and excellent biocompatibility, these NGO should be promising for bioimaging and various biomedical applications.

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DOI: https://doi.org/10.1039/C3CP52883A
Article type: Paper
Submitted: 10 Jul 2013
Accepted: 20 Sep 2013
First published: 24 Sep 2013

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Phys. Chem. Chem. Phys., 2013,15, 19013-19018

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Size tunable fluorescent nano-graphite oxides: preparation and cell imaging applications

X. Zhang, S. Wang, M. Liu, B. Yang, L. Feng, Y. Ji, L. Tao and Y. Wei, Phys. Chem. Chem. Phys., 2013, 15, 19013 DOI: 10.1039/C3CP52883A

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Physical Chemistry Chemical Physics

Size tunable fluorescent nano-graphite oxides: preparation and cell imaging applications†

Abstract

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Size tunable fluorescent nano-graphite oxides: preparation and cell imaging applications

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