Issue 85, 2013

2,4-Diamino-6,7-dimethylpteridine as a fluorescent ligand for binding and sensing an orphan cytosine in RNA duplexes

Abstract

We report on a new fluorescent ligand, 2,4-diamino-6,7-dimethylpteridine, that can strongly and selectively bind to an orphan cytosine opposite an abasic site in RNA duplexes. We describe a significant effect of the substituents attached to the pteridine ring on the binding behavior in comparison with a structurally-similar pteridine derivative.

Graphical abstract: 2,4-Diamino-6,7-dimethylpteridine as a fluorescent ligand for binding and sensing an orphan cytosine in RNA duplexes

Supplementary files

Article information

Article type
Communication
Submitted
09 Aug 2013
Accepted
05 Sep 2013
First published
05 Sep 2013

Chem. Commun., 2013,49, 9983-9985

2,4-Diamino-6,7-dimethylpteridine as a fluorescent ligand for binding and sensing an orphan cytosine in RNA duplexes

Y. Sato, Y. Toriyabe, S. Nishizawa and N. Teramae, Chem. Commun., 2013, 49, 9983 DOI: 10.1039/C3CC46085A

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