Issue 38, 2013
From the journal:

Chemical Communications

Thienopyrrole-expanded BODIPY as a potential NIR photosensitizer for photodynamic therapy†‡

Yongchao Yang,a   Qiuli Guo,a   Huachao Chen,a   Zhikuan Zhou,a   Zijian Guoa  and  Zhen Shen*a  

* Corresponding authors

a State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructures, Nanjing 210093, P. R. China
E-mail: zshen@nju.edu.cn
Fax: +86 (0)25-83314502
Tel: +86 (0)25-83686679

Abstract

The synthesis and characterization of a highly photostable bromo-substituted BODIPY dye (I) fused-ring-expanded with thienopyrrole moieties is reported. The results of MTT assays and flow cytometric analyses in living HeLa cells demonstrate that I has a high singlet oxygen quantum yield (ΦΔ = 0.63) and exhibits photocytotoxicity upon irradiation in the NIR region making it potentially suitable for use in PDT.

Graphical abstract: Thienopyrrole-expanded BODIPY as a potential NIR photosensitizer for photodynamic therapy

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Article information

DOI
https://doi.org/10.1039/C3CC40746B
Article type
Communication
Submitted
29 Jan 2013
Accepted
06 Mar 2013
First published
13 Mar 2013

Chem. Commun., 2013,49, 3940-3942

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Thienopyrrole-expanded BODIPY as a potential NIR photosensitizer for photodynamic therapy

Y. Yang, Q. Guo, H. Chen, Z. Zhou, Z. Guo and Z. Shen, Chem. Commun., 2013, 49, 3940 DOI: 10.1039/C3CC40746B

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