Issue 24, 2013
From the journal:

Chemical Communications

Controlled branching of polyglycidol and formation of protein–glycidol bioconjugatesvia a graft-from approach with “PEG-like” arms†

Benjamin R. Spears,a   Julian Waksal,a   Caitlin McQuade,a   Laura Laniera  and  Eva Harth*a  

* Corresponding authors

a Vanderbilt University, Department of Chemistry, 7619 Stevenson Center, Nashville, Tennessee, USA
E-mail: eva.harth@vanderbilt.edu
Fax: 001 615-343 1234
Tel: 001 343 3405

Abstract

The control of the branching in polyglycidols as semibranched alternatives to traditional polyglycidols is presented. The relative abundance of dendritic carbons is lowered by five-fold compared to hyperbranched polyglycidols. It is the first example of tailoring the branching in polyglycidol and creating protein–glycidol bioconjugates as alternatives to pegylated biostructures.

Graphical abstract: Controlled branching of polyglycidol and formation of protein–glycidol bioconjugates via a graft-from approach with “PEG-like” arms

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Article information

DOI
https://doi.org/10.1039/C3CC38369E
Article type
Communication
Submitted
21 Nov 2012
Accepted
24 Jan 2013
First published
24 Jan 2013

Chem. Commun., 2013,49, 2394-2396

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Controlled branching of polyglycidol and formation of protein–glycidol bioconjugates via a graft-from approach with “PEG-like” arms

B. R. Spears, J. Waksal, C. McQuade, L. Lanier and E. Harth, Chem. Commun., 2013, 49, 2394 DOI: 10.1039/C3CC38369E

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