Issue 3, 2012
From the journal:

Molecular BioSystems

An OR logic gate based on two molecular beacons

Jing Guoa  and  Renqiang Yang*a  

* Corresponding authors

a Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, 189 Songling Rd., Qingdao 266101, China
E-mail: yangrq@qibebt.ac.cn
Tel: +86-532-80662700

Abstract

Design of elementary molecular logic gates is the key and the fundamental of performing complicated Boolean calculations. Herein, we report a strategy for constructing a DNA-based OR gate by using the mechanism of sequence recognition and the principle of fluorescence resonance energy transfer (FRET). In this system, the gate is entirely composed of a single strand of DNA (A, B and C) and the inputs are the molecular beacon probes (MB1 and MB2). Changes in fluorescence intensity confirm the realization of the OR logic operation and electrophoresis experiments verify these results. Our successful application of DNA to perform the binary operation represents that DNA can serve as an efficient biomaterial for designing molecular logic gates and devices.

Graphical abstract: An OR logic gate based on two molecular beacons

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Article information

DOI
https://doi.org/10.1039/C2MB05477A
Article type
Paper
Submitted
17 Nov 2011
Accepted
20 Dec 2011
First published
26 Jan 2012

Mol. BioSyst., 2012,8, 927-930

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An OR logic gate based on two molecular beacons

J. Guo and R. Yang, Mol. BioSyst., 2012, 8, 927 DOI: 10.1039/C2MB05477A

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