Issue 76, 2012
From the journal:

Chemical Communications

Detection of bond formations by DNA-programmed chemical reactions and PCR amplification†

Yizhou Li,a   Mingda Zhang,a   Chi Zhanga  and  Xiaoyu Li*a  

* Corresponding authors

a Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, Beijing National Laboratory of Molecular Sciences (BNLMS), College of Chemistry and Molecular Engineering, Peking University, 202 Chengfu Rd., Beijing, China
E-mail: xiaoyuli@pku.edu.cn
Fax: +86 10-62751708
Tel: +86 10-62752665

Abstract

A system capable of performing both DNA-templated chemical reactions and detection of bond formations is reported. Photocleavable DNA templates direct reactions. Products from bond-forming events re-ligate original templates, amplifiable by PCR, therefore distinguishing bond formation from background. This system provides a novel approach for discovering potential new chemical reactions.

Graphical abstract: Detection of bond formations by DNA-programmed chemical reactions and PCR amplification

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Article information

DOI
https://doi.org/10.1039/C2CC35230C
Article type
Communication
Submitted
20 Jul 2012
Accepted
07 Aug 2012
First published
09 Aug 2012

Chem. Commun., 2012,48, 9513-9515

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Detection of bond formations by DNA-programmed chemical reactions and PCR amplification

Y. Li, M. Zhang, C. Zhang and X. Li, Chem. Commun., 2012, 48, 9513 DOI: 10.1039/C2CC35230C

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