Issue 19, 2012

Development of a pH-activatable fluorescent probe and its application for visualizing cellular pH change

Abstract

Novel pH-activatable fluorescent probes with various pKa values have been developed utilizing 4-nitro-benzo[1,2,5]oxadiazole derivatives (NBD) as fluorophores and piperazine moieties as proton receptors. Under acidic conditions, probe FoPz displayed significant fluorescent enhancement of about 30 fold with a pKa value of 5.70 and it responds rapidly and sensitively to intracellular pH distributions and cellular pH fluctuations.

Graphical abstract: Development of a pH-activatable fluorescent probe and its application for visualizing cellular pH change

Supplementary files

Article information

Article type
Communication
Submitted
21 May 2012
Accepted
23 Jul 2012
First published
24 Jul 2012

Analyst, 2012,137, 4418-4420

Development of a pH-activatable fluorescent probe and its application for visualizing cellular pH change

R. Huang, S. Yan, X. Zheng, F. Luo, M. Deng, B. Fu, Y. Xiao, X. Zhao and X. Zhou, Analyst, 2012, 137, 4418 DOI: 10.1039/C2AN35671F

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