Issue 3, 2012

Domino reactions for the synthesis of various α-substituted nitro alkenes

Abstract

Efficient one-pot methods for the synthesis of variously functionalised conjugated nitro alkenes have been reported. Despite the utility in different fields of these compounds, only a few multi-step syntheses have been reported in the literature, giving the target compounds in low overall yields. α-Nitro acrylates or cinnamates, α-nitro α,β-unsaturated ketones and, most importantly, aromatic and heteroaromatic (E)- 2-nitro allylic alcohols, compounds characterised by a well-known anticancer activity, were obtained in high yields and high diastereomeric purity by a domino condensation-dehydration process.

Graphical abstract: Domino reactions for the synthesis of various α-substituted nitro alkenes

Supplementary files

Article information

Article type
Paper
Submitted
26 Jul 2011
Accepted
12 Sep 2011
First published
14 Sep 2011

Org. Biomol. Chem., 2012,10, 524-528

Domino reactions for the synthesis of various α-substituted nitro alkenes

S. Fioravanti, L. Pellacani and M. C. Vergari, Org. Biomol. Chem., 2012, 10, 524 DOI: 10.1039/C1OB06260C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements