Issue 19, 2011
From the journal:

Chemical Communications

Cationic supramolecular nanoparticles for co-delivery of gene and anticancer drug†

Qi-Da Hu,‡ad   Hui Fan,‡be   Yuan Ping,c   Wen-Quan Liang,b   Gu-Ping Tang*a  and  Jun Li*c  

* Corresponding authors

a Institute of Chemical Biology and Pharmaceutical Chemistry, Zhejiang University, Hangzhou 310028, China
E-mail: tangguping@yahoo.com.cn
Tel: +86 571 88273284

b Department of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China

c Division of Bioengineering, Faculty of Engineering, National University of Singapore, 7 Engineering Drive 1, Singapore 117574, Singapore
E-mail: bielj@nus.edu.sg
Tel: +65 6516 7273

d Department of General Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China

e Department of Pharmacy, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 31016, China

Abstract

Self-assembly supramolecular nanoparticles (SNPs) are synthesized using polyethylenimine (PEI) crosslinked by cyclodextrins (CyDs), adamantyl doxorubicin and plasmidDNA. SNPs successfully conduct the cooperative co-delivery of chemotherapeutic anticancer drug and plasmidDNAin vitro and in vivo.

Graphical abstract: Cationic supramolecular nanoparticles for co-delivery of gene and anticancer drug

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Article information

DOI
https://doi.org/10.1039/C1CC10721F
Article type
Communication
Submitted
07 Feb 2011
Accepted
21 Mar 2011
First published
06 Apr 2011

Chem. Commun., 2011,47, 5572-5574

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Cationic supramolecular nanoparticles for co-delivery of gene and anticancer drug

Q. Hu, H. Fan, Y. Ping, W. Liang, G. Tang and J. Li, Chem. Commun., 2011, 47, 5572 DOI: 10.1039/C1CC10721F

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