Issue 1, 2011

First total synthesis of (−)- and (+)-6-O-desmethylantofine

Abstract

The first total synthesis of (−)-6-O-desmethylantofine (A) and its unnatural enantiomer (+)-6-O-desmethylantofine (B) is described. The synthetic route is efficient and practical with easily available glutamic acid dimethyl ester hydrochloride as the chiral material under mild conditions.

Graphical abstract: First total synthesis of (−)- and (+)-6-O-desmethylantofine

Supplementary files

Article information

Article type
Paper
Submitted
18 Jun 2010
Accepted
12 Aug 2010
First published
04 Nov 2010

Org. Biomol. Chem., 2011,9, 141-145

First total synthesis of (−)- and (+)-6-O-desmethylantofine

M. Wu, L. Li, B. Su, Z. Liu and Q. Wang, Org. Biomol. Chem., 2011, 9, 141 DOI: 10.1039/C0OB00287A

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