Issue 6, 2011

Chiral trifluoromethylphosphines: a new stereoselective synthesis of Josiphos-type ligands containing two stereogenic phosphorus atoms

Abstract

Intramolecular nucleophilic substitution of a trifluoromethyl group to form a 1,2-diphosphole derivative followed by the sequential addition of an alkylating agent and a carbanion are the key steps in the stereoselective synthesis of novel ferrocenyl diphosphines for asymmetric catalysis.

Graphical abstract: Chiral trifluoromethylphosphines: a new stereoselective synthesis of Josiphos-type ligands containing two stereogenic phosphorus atoms

Supplementary files

Article information

Article type
Communication
Submitted
25 Oct 2010
Accepted
22 Nov 2010
First published
06 Dec 2010

Chem. Commun., 2011,47, 1896-1898

Chiral trifluoromethylphosphines: a new stereoselective synthesis of Josiphos-type ligands containing two stereogenic phosphorus atoms

J. F. Buergler and A. Togni, Chem. Commun., 2011, 47, 1896 DOI: 10.1039/C0CC04606J

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