Issue 47, 2010
From the journal:

Chemical Communications

Synthesis, characterization, and computed tomography imaging of a tantalum oxidenanoparticle imaging agent†

Peter J. Bonitatibus, Jr.,*a   Andrew S. Torres,a   Gregory D. Goddard,a   Paul F. FitzGeralda  and  Amit M. Kulkarnia  

* Corresponding authors

a GE Global Research, Chemical Technology and Materials Characterization Laboratory, Niskayuna, USA
E-mail: bonitati@ge.com

Abstract

Water-soluble ≤6 nm tantalum oxide nanoparticles have been synthesized and characterized in solution using HPLC-ICP, DLS, and multinuclear NMR. Nanoparticle formulation permitted intravenous injection, in vivo imaging, and subsequent renal clearance. A clinical CT scanner provided excellent resolution following agent injection, and distribution to the arterial system was visualized. In vitro CT imaging studies indicated that at equal molar concentration of tantalum and iodine, tantalum produced greater image contrast than iodine across the diagnostic X-ray spectrum with contrast benefit increasing with peak X-ray energy.

Graphical abstract: Synthesis, characterization, and computed tomography imaging of a tantalum oxide nanoparticle imaging agent

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Article information

DOI
https://doi.org/10.1039/C0CC03302B
Article type
Communication
Submitted
17 Aug 2010
Accepted
01 Oct 2010
First published
25 Oct 2010

Chem. Commun., 2010,46, 8956-8958

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Synthesis, characterization, and computed tomography imaging of a tantalum oxide nanoparticle imaging agent

P. J. Bonitatibus, Jr., A. S. Torres, G. D. Goddard, P. F. FitzGerald and A. M. Kulkarni, Chem. Commun., 2010, 46, 8956 DOI: 10.1039/C0CC03302B

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