Issue 4, 2010
From the journal:

Chemical Communications

Peptide-based activity-based probes (ABPs) for target-specific profiling of proteintyrosine phosphatases (PTPs)†

Karunakaran A. Kalesh,a   Lay Pheng Tan,b   Kai Lu,b   Liqian Gao,c   Jigang Wangb  and  Shao Q. Yao*abc  

* Corresponding authors

a Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543
E-mail: chmyaosq@nus.edu.sg
Fax: (65) 67791691
Tel: (65) 65162925

b Department of Biological Sciences, National University of Singapore, 3 Science Drive 3, Singapore 117543

c NUS MedChem Program of the Life Sciences Institute, National University of Singapore, 3 Science Drive 3, Singapore 117543

Abstract

Synthesis of a novel unnatural amino acid (2-FMPT) for the solid-phase synthesis of peptide-based probes suitable for target-specific activity-based profiling of protein tyrosine phosphatases from crude proteomes is reported.

Graphical abstract: Peptide-based activity-based probes (ABPs) for target-specific profiling of protein tyrosine phosphatases (PTPs)

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Article information

DOI
https://doi.org/10.1039/B919744C
Article type
Communication
Submitted
22 Sep 2009
Accepted
02 Nov 2009
First published
17 Nov 2009

Chem. Commun., 2010,46, 589-591

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Peptide-based activity-based probes (ABPs) for target-specific profiling of protein tyrosine phosphatases (PTPs)

K. A. Kalesh, L. P. Tan, K. Lu, L. Gao, J. Wang and S. Q. Yao, Chem. Commun., 2010, 46, 589 DOI: 10.1039/B919744C

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