Issue 4, 2010
From the journal:

Chemical Society Reviews

Thiol-click chemistry: a multifaceted toolbox for small molecule and polymer synthesis†‡

Charles E. Hoyle,a   Andrew B. Loweb  and  Christopher N. Bowman*c  

* Corresponding authors

a School of Polymers and High Performance Materials, University of Southern Mississippi, Hattiesburg, USA

b Centre for Advanced Macromolecular Design (CAMD), School of Chemical Sciences & Engineering, University of New South Wales, Sydney, Australia

c Department of Chemical and Biological Engineering, University of Colorado, Boulder, USA
E-mail: Christopher.Bowman@Colorado.edu

Abstract

The merits of thiol-click chemistry and its potential for making new forays into chemical synthesis and materials applications are described. Since thiols react to high yields under benign conditions with a vast range of chemical species, their utility extends to a large number of applications in the chemical, biological, physical, materials and engineering fields. This critical review provides insight into emerging venues for application as well as new mechanistic understanding of this exceptional chemistry in its many forms (81 references).

Graphical abstract: Thiol-click chemistry: a multifaceted toolbox for small molecule and polymer synthesis

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Article information

DOI
https://doi.org/10.1039/B901979K
Article type
Critical Review
Submitted
04 Sep 2009
First published
09 Feb 2010

Chem. Soc. Rev., 2010,39, 1355-1387

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Thiol-click chemistry: a multifaceted toolbox for small molecule and polymer synthesis

C. E. Hoyle, A. B. Lowe and C. N. Bowman, Chem. Soc. Rev., 2010, 39, 1355 DOI: 10.1039/B901979K

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