Issue 23, 2008
From the journal:

Organic & Biomolecular Chemistry

Rhodium catalysed conjugate addition of a chiral alkenyltrifluoroborate salt: the enantioselective synthesis of hermitamides A and B

Christopher G. Frost,*a   Stephen D. Penrosea  and  Robert Gleaveb  

* Corresponding authors

a Department of Chemistry, University of Bath, Claverton Down, Bath, UK
E-mail: c.g.frost@bath.ac.uk
Fax: +44 (0)1225 386231
Tel: +44 (0)1225 386142

b Gastrointestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex, UK

Abstract

The concise enantioselective synthesis of hermitamides A and B is presented utilising a rhodium catalysed conjugate addition reaction to introduce the side chain and chiral information in a single step via an alkenyltrifluoroborate salt.

Graphical abstract: Rhodium catalysed conjugate addition of a chiral alkenyltrifluoroborate salt: the enantioselective synthesis of hermitamides A and B

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Article information

DOI
https://doi.org/10.1039/B812897A
Article type
Paper
Submitted
25 Jul 2008
Accepted
12 Sep 2008
First published
18 Oct 2008

Org. Biomol. Chem., 2008,6, 4340-4347

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Rhodium catalysed conjugate addition of a chiral alkenyltrifluoroborate salt: the enantioselective synthesis of hermitamides A and B

C. G. Frost, S. D. Penrose and R. Gleave, Org. Biomol. Chem., 2008, 6, 4340 DOI: 10.1039/B812897A

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