Issue 18, 2008

Regio- and chemoselective magnesiation of protected uracils and thiouracils using TMPMgCl·LiCl and TMP2Mg·2LiCl

Abstract

Two successive regio- and chemoselective magnesiations using TMPMgCl·LiCl and TMP2Mg·2LiCl enable the full functionalization of protected uracils and thiouracils in good to excellent yields.

Graphical abstract: Regio- and chemoselective magnesiation of protected uracils and thiouracils using TMPMgCl·LiCl and TMP2Mg·2LiCl

Supplementary files

Article information

Article type
Communication
Submitted
21 Jul 2008
Accepted
22 Jul 2008
First published
31 Jul 2008

Org. Biomol. Chem., 2008,6, 3237-3239

Regio- and chemoselective magnesiation of protected uracils and thiouracils using TMPMgCl·LiCl and TMP2Mg·2LiCl

M. Mosrin, N. Boudet and P. Knochel, Org. Biomol. Chem., 2008, 6, 3237 DOI: 10.1039/B812528G

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