Issue 2, 2009
From the journal:

Chemical Society Reviews

Amide bond formation: beyond the myth of coupling reagents

Eric Valeur†*a  and  Mark Bradley*a  

* Corresponding authors

a University of Edinburgh, School of Chemistry, West Mains Road, Edinburgh, UK
E-mail: mark.bradley@ed.ac.uk
Fax: (+44) 131 650 6453
Tel: (+44) 131 650 4820

Abstract

Amide bond formation is a fundamentally important reaction in organic synthesis, and is typically mediated by one of a myriad of so-called coupling reagents. This critical review is focussed on the most recently developed coupling reagents with particular attention paid to the pros and cons of the plethora of “acronym” based reagents. It aims to demystify the process allowing the chemist to make a sensible and educated choice when carrying out an amide coupling reaction (179 references).

Graphical abstract: Amide bond formation: beyond the myth of coupling reagents

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Article information

DOI
https://doi.org/10.1039/B701677H
Article type
Critical Review
Submitted
23 Jun 2008
First published
04 Dec 2008

Chem. Soc. Rev., 2009,38, 606-631

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Amide bond formation: beyond the myth of coupling reagents

E. Valeur and M. Bradley, Chem. Soc. Rev., 2009, 38, 606 DOI: 10.1039/B701677H

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