Issue 1, 2008
From the journal:

Chemical Society Reviews

Automated oligosaccharide synthesis†

Peter H. Seeberger*a  

* Corresponding authors

a Laboratory for Organic Chemistry, Swiss Federal Institute of Technology (ETH) Zürich, HCI F 315, Wolfgang-Pauli-Str. 10, CH-8093 Zürich, Switzerland
E-mail: seeberger@org.chem.ethz.ch
Fax: 41 44 633 1235
Tel: 41 44 633 2103

Abstract

Peptides and oligonucleotides are prepared by automated synthesizers that can be operated by non-specialists. Carbohydrates have been hard to assemble, but the increasing awareness of the biological importance of this class of complex repeating biopolymers has prompted efforts to accelerate their synthesis. This tutorial review defines the state of the art of automated solid phase oligosaccharide synthesis and identifies areas in need of further innovation. Application of the automated synthesis method to prepare a malaria vaccine candidate is briefly highlighted.

Graphical abstract: Automated oligosaccharide synthesis

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Article information

DOI
https://doi.org/10.1039/B511197H
Article type
Tutorial Review
Submitted
27 Jun 2007
First published
20 Aug 2007

Chem. Soc. Rev., 2008,37, 19-28

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Automated oligosaccharide synthesis

P. H. Seeberger, Chem. Soc. Rev., 2008, 37, 19 DOI: 10.1039/B511197H

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