Issue 6, 2004
From the journal:

Organic & Biomolecular Chemistry

Stereoselective preparation of conjugated E-enynes from E-vinylic tellurides and terminal alkynesvia Sonogashira cross-coupling†

Gilson Zeni,*a   Diego Alves,a   Jesus M. Pena,a   Antonio L. Braga,a   Helio A. Stefanib  and  Cristina W. Nogueiraa  

* Corresponding authors

a Departamento de Química, Laboratório de Bioquímica Toxicológica, UFSM, Santa Maria, RS, Brazil
E-mail: gzeni@quimica.ufsm.br

b Faculdade de Ciências Farmacêuticas, USP, São Paulo, SP, Brazil

Abstract

E-Vinylic tellurides undergo a direct cross-coupling reaction with terminal alkynes in the presence of palladium(II)/CuI in Et3N at room temperature to give E-enynes in good yields. The methodology represents a general and efficient protocol for carrying out the synthesis of E-enynes under mild conditions with complete retention of configuration.

Graphical abstract: Stereoselective preparation of conjugated E-enynes from E-vinylic tellurides and terminal alkynes via Sonogashira cross-coupling

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Article information

DOI
https://doi.org/10.1039/B401059K
Article type
Communication
Submitted
23 Jan 2004
Accepted
04 Feb 2004
First published
09 Feb 2004

Org. Biomol. Chem., 2004,2, 803-805

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Stereoselective preparation of conjugated E-enynes from E-vinylic tellurides and terminal alkynes via Sonogashira cross-coupling

G. Zeni, D. Alves, J. M. Pena, A. L. Braga, H. A. Stefani and C. W. Nogueira, Org. Biomol. Chem., 2004, 2, 803 DOI: 10.1039/B401059K

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