Issue 23, 2002
From the journal:

Chemical Communications

Application of hitherto unexplored macrocyclization strategies in the epothilone series: novel epothilone analogs by total synthesis†

Jon T. Njardarson,a   Kaustav Biswasa  and  Samuel J. Danishefsky*ab  

* Corresponding authors

a Laboratory for Bioorganic Chemistry, The Sloan-Kettering Institute for Cancer Research, New York, NY, USA
E-mail: s-danishefsky@ski.mskcc.org

b Department of Chemistry, Columbia University, Havemeyer Hall, New York, NY, USA

Abstract

A total synthesis of Epothilone 490 and a synthesis of 11-hydroxy dEpoB utilizing a vinyl-boronate cross-metathesis followed by a Suzuki macrocyclization. A mild route to reach aldehydes from terminal olefins, anticipating Nozaki–Kishi macrocyclization is described.

Graphical abstract: Application of hitherto unexplored macrocyclization strategies in the epothilone series: novel epothilone analogs by total synthesis

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Article information

DOI
https://doi.org/10.1039/B209941A
Article type
Communication
Submitted
09 Oct 2002
Accepted
16 Oct 2002
First published
30 Oct 2002

Chem. Commun., 2002, 2759-2761

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Application of hitherto unexplored macrocyclization strategies in the epothilone series: novel epothilone analogs by total synthesis

J. T. Njardarson, K. Biswas and S. J. Danishefsky, Chem. Commun., 2002, 2759 DOI: 10.1039/B209941A

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