SCHEDULED MAINTENANCE
Synthesis and biological evaluation of potential substrates for the isolation of the strigol receptor
Abstract
A series of analogues derived from (+)-strigol, which is
a germination stimulant for seeds of the parasitic weeds
Striga and Orobanche, has been prepared. For
the isolation and characterization of the strigol receptor,
labelled analogues are required in which a photoreactive function
may be incorporated. The synthetic strategy allows for the
synthesis of a range of A-ring substituted analogues of GR24
(which is a strigol analogue), including fluorescent dansyl GR24
10. Bioassays reveal that the stimulatory activity of these
analogues in the seed germination of Striga hermonthica
is retained.
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