Issue 3, 1990

Mono-N-alkylation of α-aminoacetonitriles. A novel route to unsymmetrical secondary amines

Abstract

Mannich-type condensation products of an aldehyde with an α-aminoacetonitrile and benzotriazole are treated with sodium borohydride or with a Grignard reagent to give unsymmetrical N,N-dialkylaminoacetonitriles, which, on decyanomethylation, provide unsymmetrical secondary amines.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1990, 667-672

Mono-N-alkylation of α-aminoacetonitriles. A novel route to unsymmetrical secondary amines

A. R. Katritzky, M. Latif and L. Urogdi, J. Chem. Soc., Perkin Trans. 1, 1990, 667 DOI: 10.1039/P19900000667

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