The enantiospecific synthesis of (3S,6R)-6-ethoxycarbonyl-3-(p-hydroxybenzyl)piperazin-2-one (1) and (3S)-1-(ethoxycarbonylmethyl)-3-(p-hydroxybenzyl)piperazin-2-one (2) and their enantiomers is described. The chiral C-6 centre of (1) is generated by a regiospecific protonation of the enamide precursor.
J. DiMaio and B. Belleau, J. Chem. Soc., Perkin Trans. 1, 1989, 1687 DOI: 10.1039/P19890001687
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