Issue 2, 1989
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

N-Hydroxy amides. Part 6. Synthesis and spectroscopic properties of 1-hydroxypiperazine-2,5-diones

Masayasu Akiyama,   Akira Katoh  and  Yuko Tsuchiya  

Abstract

1-Hydroxypiperazine-2,5-diones (3a–f) are prepared in good yields, starting with Boc-L-amino acids and N-benzyloxyglycine methyl ester. The rate of cyclisation for N-hydroxy and N-benzyloxydipeptide methyl esters are 38–77 times as large as that of phenylalanylglycine methyl ester. The c.d., 1H n.m.r., i.r., and u.v. spectral data of 1-hydroxypiperazine-2,5-diones are similar to those of the corresponding piperazinediones. A difference is noted in the i.r. carbonyl frequencies in the solid state.

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Article information

DOI
https://doi.org/10.1039/P19890000235
Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1989, 235-239

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N-Hydroxy amides. Part 6. Synthesis and spectroscopic properties of 1-hydroxypiperazine-2,5-diones

M. Akiyama, A. Katoh and Y. Tsuchiya, J. Chem. Soc., Perkin Trans. 1, 1989, 235 DOI: 10.1039/P19890000235

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