Issue 3, 1988
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Asymmetric syntheses. Part 2. Reduction of ketones with chiral sodium borohydride-lactic acid derivative systems

Giorgio Bianchi,   Fiorella Achilli,   Anna Gamba  and  Dina Vercesi  

Abstract

Asymmetric reduction of acetophenone, propiophenone, and 2-acetylnaphthalene using chirally modified reagents prepared from sodium borohydride and optically active (S)-lactic acid derivatives produced the corresponding optically active (R) alcohols with enantiomeric excesses as high as 38.3%. The extent of asymmetric synthesis was dependent on the catalyst, the solvent, and the reaction conditions. 1H and 13C N.m.r. data for sodium borohydride chiral species are reported.

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Article information

DOI
https://doi.org/10.1039/P19880000417
Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1988, 417-422

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Asymmetric syntheses. Part 2. Reduction of ketones with chiral sodium borohydride-lactic acid derivative systems

G. Bianchi, F. Achilli, A. Gamba and D. Vercesi, J. Chem. Soc., Perkin Trans. 1, 1988, 417 DOI: 10.1039/P19880000417

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