Issue 0, 1987
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

The chemistry of N-substituted benzotriazoles. Part 4. A novel and versatile method for the mono-N-alkylation of aromatic and heteroaromatic amines

Alan R. Katritzky,   Stanislaw Rachwal  and  Bogumila Rachwal  

Abstract

Mono-N-alkylation of aromatic and heteroaromatic amines is achieved in high yield by NaBH4 reduction of the adducts formed from benzotriazole, aliphatic aldehydes and the amines. Reaction of the same adducts with Grignard reagents gives N-(secondary alkyl)arylamines. Carboxy groups need no protection and nitro groups are unaffected. Adenine is mono-N-alkylated in high yield.

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Article information

DOI
https://doi.org/10.1039/P19870000805
Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1987, 805-809

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The chemistry of N-substituted benzotriazoles. Part 4. A novel and versatile method for the mono-N-alkylation of aromatic and heteroaromatic amines

A. R. Katritzky, S. Rachwal and B. Rachwal, J. Chem. Soc., Perkin Trans. 1, 1987, 805 DOI: 10.1039/P19870000805

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